HLA class II association with Type I allergy to house dust mite and Japanese cedar pollen in Japanese subjects.
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated the incidence of the association of HLA class II phenotype and specific IgE responsiveness against house dust mite (HDM) and/or Japanese cedar pollen (Jc) in 176 patients with allergic rhinitis, with or without bronchial asthma, and 107 nonallergic subjects. Specific IgE antibody titration against the purified allergens Der f1 and Der f2 from HDM, and against Cry J1 and Cry J2 from Jc, was performed by using enzyme-linked immunosorbent assay (ELISA) and radio-immunoassay (RIA) in sera from all subjects. HLA class II oligotyping was performed by the polymerase chain reaction sequence specific oligonucleotide (PCR-SSO) method on the DRB1*, DQA1*, DQB1* and DPB1* alleles using peripheral blood cells. The high IgE responders ≥ class 4 to the purified allergens were identified by using the IgE antibody reference concentration obtained by ELISA, RIA and routine IgE CAP RAST. Compared to the controls, the patients with both rhinitis and asthma showed significantly higher frequencies of DRB1* 0901, DQB1* 0303, and DPB1* 0401 alleles. High IgE responsiveness to HDM was associated with DRB1* 1101, 0901, DQB1* 0303, and DPB1*0401 alleles. The patients with anti-Der f1 IgE antibody concentration exceeding 72.2 ng/mL showed significantly elevated frequencies for DQB1*0401 and DPB1*0401 alleles, and those with anti Der f2 IgE antibody concentration exceeding 46.2 ng/mL showed significantly elevated frequencies for DPB1*0401 and 0901 alleles. High IgE responsiveness to Jc with Cry j1 and Cry j2 was associated with the DRB1* 1201 alleles.
- Japanese Society of Allergologyの論文
Japanese Society of Allergology | 論文
- Reliability and Validity of the Self-report Quality of Life Questionnaire for Japanese School-aged Children with Asthma (JSCA-QOL v.3)
- Development of the Revised Final Version of the Quality of Life of Japanese School Aged Children with Asthma Questionnaire : The Characteristics of the Low QOL Scoring Group and Development of an Evaluation Form
- Development of the Revised Final Version of the Quality of Life of Japanese School Aged Children with Asthma Questionnaire : The Characteristics of the Low QOL Scoring Group and Development of an Evaluation Form
- An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis
- Allergenic importance of 22 species of Japanese chironomid midges