Effect of Double Dose (240 mg/day) Fexofenadine in Patients with Urticaria and Eczema/Dermatitis : A Pilot Study
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概要
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We have researched the effects and side effect (sleepiness) of double dose (240 mg/day) fexofenadine in itchy dermatitis, such as urticaria and atopic dermatitis. Patients who complained of itching with either urticaria or eczema (including atopic dermatitis) were first treated with a regular dose (60 mg, twice a day) fexofenadine for 2 weeks. Patients' itch and daytime sleepiness was judged by a visual analogue scale (VAS). Patients with less than 30% reduction in the itch VAS score were further treated with a double dose (120 mg, twice a day) fexofenadine for 4 more weeks. Also, the switch cases who had received other anti-histamines were treated with a double dose from the beginning. A total of 47 patients were enrolled, and 66% of the patients achieved more than 30% reduction of the VAS score with the regular dose. Among 13 patients who did not achieve 30% reduction, 8 (62%) showed more than 50% reduction in the VAS score after increasing the fexofenadine to double dose. All of the nine cases who were switched from regular dose antihistamine to double dose fexofenadine showed more than 50% VAS reduction. Thus patients' VAS scores decreased more than 50% when regular dose was not successful, and it was even 100% in the switch cases. The side effect of sleepiness, possibly due to the increase of fexofenadine dose, was observed in only one case. From these results, we conclude that the double dose of fexofenadine is very effective in itchy dermatitis without side effects.
- 日本皮膚科学会西部支部の論文
日本皮膚科学会西部支部 | 論文
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