前癌細胞核の微細構造
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Hyperplastic nodules developed in rat liver as the result of feeding diets containing 3'-methyl-4-dimethylaminoazobenzene, 2-fluorenyl-acetamide or DL-ethionine. There is evidence that such nodules are in a prodromal stage of cancer. The remarkable changes in ultrastructure as well as in DNA and RNA syntheses occurred in hepatocyte nuclei in the precancer liver. The striking features of these chages were enormous enlargement of nucleoli, disapperance of condensed chromatin aggregates and dense appearance of the inner layer of nuclear envelope. The ultrastructural and autoradiographic patterns of nuclei, especially of nucleoli showed that the transport of nucleolar product into the cytoplasm was blocked, and the turnover of DNA in the hyperplastic precancer cell nuclei was remarkably active as compared with that in the non-nodular portions of the same material or in the normal liver. It was revealed that the ultrastructure of cell nuclei in such diseases as the Bowen's disease, senile keratosis and leukoplakia was in a similar stage as those in precancerous hepatic nodules. The nuclear body appearing in these diseases was discussed as to the fine structure and origin. The nuclear structure in the Ewing's sarcoma and osteogenic sarcoma was compared with that of precancerous, cutaneous diseases. The intranuclear inclusions in the precancerous skin diseases were composed from protein, but those of osteogenic sarcoma from crystalline elements consisting of phospholipids.
- 日本皮膚科学会西部支部の論文
日本皮膚科学会西部支部 | 論文
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