Effects of Sex Hormones on Rat Tongue Carcinoma Induced by 4-Nitroquinoline 1-Oxide (4NQO)
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概要
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We investigated the regulatory effects of sex hormones on tongue carcinoma initiated by orally administration 4-nitroquinoline 1-oxide (4NQO) to rats. Animals of either sex were classified into three groups. The male rats in each group received an estrogen administration (Me), orchiectomy (Mor), or both treatments (Me/or) while the female rats also received testosterone administration (Ft), ovariectomy (Fov), or both treatments (Ft/ov). The differences in the carcinogenic progress among these groups were examined by macroscopic and microscopic observation of tongue tissues. The incidence of cancer in the tongue tissue was 100% in the group reinforced with testosterone (testosterone+group) (Ft, Ft/ov, Me) but only 56.0% in the group not reinforced with testosterone (testosterone-group) (Fov, Mor). These findings suggest that sex hormones play a role in the onset of 4NQO-induced tongue carcinoma.
- 東京歯科大学の論文
東京歯科大学 | 論文
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