Plasma miR-124 as a biomarker for cerebral infarction
スポンサーリンク
概要
- 論文の詳細を見る
MicroRNAs (miRNAs) are endogenous small RNAs that play an important role in various physiological processes by downregulating target genes. Recently, plasma miRNAs have been investigated as biomarkers for various diseases. In this study, miRNA array analysis in various tissues showed that miR-124 is almost exclusively expressed in the central nervous system and neuronal cells, suggesting that it might be useful as a potential biomarker for neurological diseases. We examined whether plasma concentrations of brain-specific miRNA can serve as a biomarker for cerebral infarction, where the cerebral infarction was modeled by middle cerebral artery occlusion (MCAO) in the rat. Plasma concentrations of miR-124 were significantly elevated at 6 h, and remained elevated at 48 h after MCAO introduction. Thus, plasma concentration of miR-124 provides a promising candidate biomarker for early detection of cerebral infarction.
- バイオメディカルリサーチプレスの論文
バイオメディカルリサーチプレス | 論文
- Methylseleninic acid (MSA) inhibits 17β-estradiol-induced cell growth in breast cancer T47D cells via enhancement of the antioxidative thioredoxin/ thioredoxin reductase system
- Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry
- Effect of heat on synthesis of gelatinases and pro-inflammatory cytokines in equine tendinocytes
- Histological observations on the microenvironment of osteolytic bone metastasis by breast carcinoma cell line
- Effect of inducible nitric oxide synthase on apoptosis in Candida-induced acute lung injury