Fucoidan inhibits parainfluenza virus type 2 infection to LLCMK2 cells
スポンサーリンク
概要
- 論文の詳細を見る
The effects of fucoidan and L-fucose, a fundamental major component of fucoidan, on the growth of human parainfluenza virus type 2 (hPIV-2) in LLCMK<SUB>2</SUB> cells were investigated. Fucoidan inhibited cell fusion and hemadsorption, but L-fucose only partly inhibited both. Virus RNA was not detected in the hPIV-2 infected cells cultured with fucoidan. However, L-fucose did not inhibit virus RNA synthesis. Indirect immunofluorescence study showed that virus protein synthesis was inhibited by fucoidan, but not by L-fucose. Furthermore, using a recombinant, green fluorescence protein-expressing hPIV-2, it was found that virus entry was inhibited by fucoidan, but not by L-fucose. These results suggested that fucoidan inhibited virus adsorption to the surface of the cells by binding to the cell surface and prevented infection, indicating that the sulfated polysaccharide form was important for the inhibition by fucoidan.
- バイオメディカルリサーチプレスの論文
バイオメディカルリサーチプレス | 論文
- Methylseleninic acid (MSA) inhibits 17β-estradiol-induced cell growth in breast cancer T47D cells via enhancement of the antioxidative thioredoxin/ thioredoxin reductase system
- Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry
- Effect of heat on synthesis of gelatinases and pro-inflammatory cytokines in equine tendinocytes
- Histological observations on the microenvironment of osteolytic bone metastasis by breast carcinoma cell line
- Effect of inducible nitric oxide synthase on apoptosis in Candida-induced acute lung injury