喉頭癌のリンパ節転移に関する臨床病理学的ならびに免疫組織化学的研究
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In 52 cases of T2-4 glottic carcinoma, factors that may be responsible for neck metastasis were investigated by clinicopathological and immunohistochemical techniques. These factors included clinicopathological factors such as T-staging, tissue differentiation and the ploidy pattern of nuclear DNA ; ploliferation factors such as the S-phase cell labelling index (SLI) and EGF-R; factors related to the basement membrane such as Type-4 collagen and matrix metalloproteinase 2(MMP-2); and cell adhesion factors including E-cadherin, catenin, cathepsin D and desmoglein. The correlation of each factor to neck metastasis was evaluated statistically.No significant difference was observed between T2 and T3-4, nor between any two groups of well, moderately and poorly differentiated carcinomas. No significant difference was seen between the diploid and aneuploid groups. On the other hand, cases with a positive expression of EGF-R showed a statistically higher incidence of neck metastasis than those with a nagative expression. Cases with an SLI higher than 30, especially those higher than 40, showed a greater incidence of neck metastasis than those with scores lower than 30. A significant difference was also found between the groups with positive and negative expressions of desmoglein. It was further observed that E-cadherin and catenin show the same pattern of expression, but cathepsin has an inverse correlation to them. As for the components of the basement membrane, Type-4 collagen had a close correlation with neck metastasis, and a much higher incidence of neck metastasis was found in cases with a fragmented or negative expressions. Cases with a higher tissue titer of MMP-2 that may degrade Type-4 collagen showed a higher incidence of neck metastasis. On the other hand, no significant difference was observed between the two groups with positive and negative expressions of p53 oncoprotein.
- 特定非営利活動法人 日本気管食道科学会の論文
特定非営利活動法人 日本気管食道科学会 | 論文
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