Abnormal Fatty Acid Profile of Blood Cell Phospholipids and Dietary Fatty Acid Intake in Patients with Ulcerative Colitis
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To elucidate the efficacy of dietary therapy for ulcerative colitis (UC), we analyzed the dietary fatty acid intakes, fatty acid compositions of phospholipids in the plasma and blood cells, and serum cytokines of 12 patients with UC. Correlations among fatty acid compositions in the diet, blood cell phospholipids and serum cytokines were also investigated in UC patients. Although the fat energy ratio was lower in the UC patients than in the controls, no significant difference was observed in their fatty acid intakes. Significantly higher linoleic acid levels were observed in the erythrocyte, mononuclear cell and neutrophil phospholipids of the UC patients compared with the controls. Concerning neutrophil phospholipids, two times higher levels of linoleic acid and arachidonic acid and lower levels of eicosapentaenoic acid (EPA) were observed in the UC patients compared with those in the controls. The serum TNF-α concentration was correlated positively with molar percentage of linoleic acid (r = 0.675, p < 0.02) and negatively with the n-3 polyunsaturated fatty acid (PUFA) (r = -0.584, p < 0.05) in the plasma phospholipids of UC patients. Dietary EPA intake was correlated negatively with the n-6 PUFA molar percentage in the phospholipids of the plasma, mononuclear cells and neutrophils. From these findings, we suggest that a diet high in n-3 PUFA and low in linoleic acid should be recommended for UC patients.
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日本酸化ストレス学会 JCBN事務局 | 論文
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