The effect of dexmedetomidine on transient focal cerebral ischemia in rats
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概要
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To examine the possibility that the dexmedetomidine-induced cerebral vasoconstriction deteriorates ischemic brain damage, we administered dexmedetomidine during transient focal cerebral ischemia in rats. Rats received intravenous infusions of dexmedetomidine at 0.1μg·kg<SUP>-1</SUP>·min<SUP>-1</SUP>, and 1μg·kg<SUP>-1</SUP>·min<SUP>-1</SUP> during cerebral ischemia induced by the occlusion of the middle cerebral artery with a nylon suture. Further, 5mg·kg<SUP>-1</SUP> of yohimbine combined with dexmedetomidine were also given during the cerebral ischemia. Cerebral infarction was detected in rats receiving infusions of dexmedetomidine at 0.1μg·kg<SUP>-1</SUP>·min<SUP>-1</SUP> and 1μg·kg<SUP>-1</SUP>·min<SUP>-1</SUP>1. Cerebral infarct volume was significantly larger in rats receiving dexmedetomidine infusion at 1μg·kg<SUP>-1</SUP>·min<SUP>-1</SUP> than that of rats receiving at 0.1μg·kg<SUP>-1</SUP>·min<SUP>-1</SUP>. Treatment with yohimbine significantly decreased the dexmedetomidine-induced infarct volume by 84%. Therefore, it is suggested that the infusion of high-dose dexmedetomidine aggravates ischemic brain damage following focal cerebral ischemia in rats via the activation of alpha-2 adrenoceptor.
- 日本循環制御医学会の論文
日本循環制御医学会 | 論文
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