ｃ‐Ｃｂ１の過剰発現による骨肉腫細胞抑制についての検討
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The protein product of the <I>c-Cb1</I> proto-oncogene is involved in several signaling pathways and exerts a negative regulatory function on receptor and non-receptor tyrosine kinase. We used the overexpression experiment, and demonstrated that the c-Cb1 inhibits phosphorylation of intracellular protein in osteosarcoma cell line, SaOS2. Luciferase reporter assays revealed overexpression of c-Cb1 suppressed PDGF-induced c-Fos promoter activity as well as v-Src-induced STAT3 promoter activity. Thus, our results demonstrate that c-Cb1 negatively regulates several signaling pathways in the osteosarcoma cell line, suggesting that c-Cb1 is a good candidate for gene therapy against osteosarcoma.
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