A simple flow cytometric scoring system is useful for distinguishing myelodysplastic syndromes from non-clonal anemic disorders

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Myelodysplastic syndromes (MDS) are a myeloid neoplasm characterized by abnormal differentiation, ineffectivehematopoiesis, and genetic instability with enhanced risk of transforming to acute myeloid leukemia (AML). The diagnosis ofMDS is principally made based on the percentage of blasts in the bone marrow and peripheral blood, type and degree ofdysplasia and the presence of ring sideroblasts. Recently, for making an accurate diagnosis of MDS, the aberrant antigen expressiondetection of hematopoietic cells by flow cytometry has been reported to be a useful. However, the diagnostic systemsutilized in those studies are rather complicated. We modified an existing flow cytometric scoring system (FCMSS) based onaberrancies in the myeloid lineage and evaluated its usefulness in diagnosing various anemic disorders, includingmyelodysplastic syndromes (MDS). The flow cytometric score was significantly higher in MDS patients than in those with otheranemic disorders, the exception being megaloblastic anemia (i.e., Vitamin B12 deficiency, folate deficiency). The data suggestthat our FCMSS may provide useful information for making the diagnosis of MDS and other anemic disorders.
長崎大学医学部の論文