Spontaneous Seroconversion of Hepatitis B Surface Antigen in a Young Woman with Chronic Carrier

概要

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The incidence of spontaneous seroconversion of hepatitis B surface antigen (HBsAg) in the natural history of patients with chronic hepatitis B virus (HBV) infection is considered to be low in patients aged under 40 years. The clinical course and outcome of chronic HBV infection are complex and heterogeneous, and may be influenced by many factors such as HBV genotype, viral mutations, gender, age, host immune status, other viral co-infections, and alcohol consumption. We encountered a Japanese woman in whom HBsAg seroconversion had occurred when she was 32 years old, 3 years after she had given birth without any anti-viral therapy. In this case, alcohol intake, pregnancy and delivery may have affected the host-virus interaction.
長崎大学医学部の論文