Young Age and the Presence of Hypertension Attenuate the Heart Rate-Reducing Effect of Landiolol during Emergency from Anesthesia and Tracheal Extubation
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We examined the effects of the short-acting beta-1 blocker, landiolol, on hemodynamics during emergence from anesthesia in elderly and middle-aged patients with and without hypertension. Fifty hypertensive and 50 normotensive elderly and middle-aged patients scheduled for orthopedic or gynecological surgery were selected. Immediately after the end of the surgery and termination of administration of all anesthetics, a landiolol infusion was administered at a rate of 0.125 mg/kg/min for 1 min and then decreased to 0.04 mg/kg/min until extubation. Heart rate and blood pressure were recorded every minute from immediately before the administration of landiolol up to discontinuation of landiolol, and every 5 min from the discontinuation of landiolol to 30 min after termination of the infusion. As a control, nine normotensive middle-aged and 10 normotensive elderly patients were also studied. In addition, eight hypertensive middle-aged and eight normotensive elderly patients were also evaluated with administration of a different landiolol infusion dosage. In the non-hypertensive group, with landiolol infusion, heart rate of middle-aged patients remained unchanged, while that of elderly patients decreased during emergence from anesthesia and tracheal extubation. In contrast, in the hypertensive group, the heart rate increased in middle-aged patients and remained unchanged in elderly patients with landiolol infusion during emergence and tracheal extubation. With an increase or decrease in landiolol dosage, heart rate remained unchanged during emergence and tracheal extubation in middle-aged hypertensive and elderly normotensive patients. The present study shows that the chronotropic effect of landiolol is attenuated in middle-aged patients with hypertension during emergence from anesthesia. Anesthesiologists should consider the patient's demographic data, such as age or presence of hypertension, when using landiolol for stabilizing the heart rate during emergence from anesthesia.
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日本臨床麻酔学会 | 論文
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