Associations between Blood Lipid Profiles and Risk of Myocardial Infarction Among Japanese Male Workers: 3M Study
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概要
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Aim: To examine whether fasting blood lipid profiles are associated with the risk of myocardial infarc-tion among Japanese men.<BR>Methods: We conducted a nested case-control study in the Morbidity of Myocardial Infarction Mul-ticenter Study in Japan (3M Study). For each case of myocardial infarction entered in the 3M Study between 1997 and 2000, we randomly selected two controls, matched for age (±3 years), from among the participants in risk factor surveys with no history of myocardial infarction. A total of 723 male employees (241 cases and 482 controls) aged 35 to 65 years were enrolled in the present study.<BR>Results: The subjects had significantly higher mean fasting LDL-cholesterol and triglyceride, and lower mean HDL-cholesterol than controls. The multivariable conditional odds ratio (95% confi-dence interval) for myocardial infarction after adjustment for known cardiovascular risk factors was 3.87 (1.27-11.7, p for trend <0.001) for total cholesterol [-6.71 vs <4.65 mmol/L], 3.28 (1.12-9.60, p for trend=0.001) for LDL-cholesterol [-4.64 vs <2.59 mmol/L], 0.17 (0.07-0.43, p for trend=0.001) for HDL-cholesterol [-1.55 vs <1.03 mmol/L] and 3.03 (1.37-6.70, p for trend= 0.01) for triglycerides [-2.26 vs <1.13 mmol/L].<BR>Conclusion: High total and LDL-cholesterol, low HDL-cholesterol and high triglycerides levels were independently associated with an increased risk of myocardial infarction among middle-aged Japa-nese male workers.
- 一般社団法人 日本動脈硬化学会の論文
一般社団法人 日本動脈硬化学会 | 論文
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