Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000
スポンサーリンク
概要
- 論文の詳細を見る
We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (<I>CETP</I>), lipoprotein lipase (<I>LPL</I>), hepatic lipase (<I>LIPC</I>), and apolipoprotein CIII</B> (<I>APOC3</I>), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of <I>CETP</I> polymorphism (D442G, Int14 +1 G → A, and TaqIB), <I>LPL</I> polymorphism (S447X), and <I>LIPC</I> polymorphism (−514 → CT) with HDL-cholesterol levels. We also found a significant association of <I>LPL</I> polymorphism (S447X) and <I>APOC3</I> polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.
- 一般社団法人 日本動脈硬化学会の論文
一般社団法人 日本動脈硬化学会 | 論文
- Effects of Lysosomal Protease Inhibitors on the Degradation of Acetylated Low Density Lipoprotein in Cultured Rat Peritoneal Macrophages
- Genomic Structure and Mapping of Human Orphan Receptor LXR Alpha : Upregulation of LXRa mRNA During Monocyte to Macrophage Differentiation
- The Gene Expression Profile of Human Umbilical Vein Endothelial Cells Stimulated by Tumor Necrosis Factor a Using DNA Microarray Analysis
- Participation of T Lymphocytes and Macrophages in Atherogenesis
- Immunohistochemical and Quantitative Analysis of Cellular and Extracellular Components of Aortic Atherosclerosis in WHHL Rabbits