Oral Vitamin C Ameliorates Smoking-induced Arterial Wall Stiffness in Healthy Volunteers
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概要
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We have investigated whether the oral administration of vitamin C could prevent smoking-induced acceleration of arterial stiffness in healthy volunteers. Subjects were pretreated with 2 g vitamin C and their heart rate (HR), mean blood pressure (MBP), and brachial-ankle pulse wave velocity (baPWV) were measured before and after smoking. Smoking significantly increased the HR, MBP, baPWV (13, 6.4, 7.0%). Vitamin C treatment significantly reduced the smoking-induced elevation in baPWV at 0 min (− 58.5%, <I>p</I> = 0.0002) without affecting HR or MBP. These findings suggest that oral vitamin C treatment prevents smoking-induced acceleration in arterial stiffness through reducing endothelial dysfunction.
- 一般社団法人 日本動脈硬化学会の論文
一般社団法人 日本動脈硬化学会 | 論文
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