Cytotoxicity and Inhibition of Nitric Oxide in Lipopolysaccharide Induced Mammalian Cell Lines by Aqueous Extracts of Brown Seaweed

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概要

• 論文の詳細を見る

• Aqueous extracts obtained from five Malaysian brown seaweeds, Sargassum duplicatum, Sargassum binderi, Sargassum fulvellum, Padina australis, and Turbinaria turbinata, were investigated for their abilities to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophage RAW 264.7 cell lines as well as to determine their chemical composition. The percentage yield of extracts varied among species, with P. australis having the lowest yield and T. turbinata having the highest yield. The chemical compositions of the extracts showed that the percentage of sulfate ions as well as uronic acid and total sugar content varied significantly. All extracts contained high fucose and inhibited NO secretion in a dose-dependent manner. Extracts of P. australis and T. turbinata dosed at 200 μg/mL were able to inhibit NO secretion by > 75%. Furthermore, cytotoxicity assays revealed that some extracts were moderately toxic, while others were not. Based on these results, brown seaweed of Malaysian origin should be investigated for the production of additional anti-inflammatory compounds.

• Japan Oil Chemists' Societyの論文

著者

• Jaswir Irwandi

  Department Of Biotechnology Engineering Faculty Of Engineering International Islamic University Mala

• Octavianti Fitri

  Faculty of Dentistry, Universiti Sains Islam Malaysia

• Salleh Mohammad

  Department of Biotechnology Engineering, International Islamic University Malaysia

• Monsur Hammed

  Department of Biotechnology Engineering, International Islamic University Malaysia

• Simsek Senay

  Department of Cereal Science, Faculty of Plant Science, North Dakota State University

• Amid Azura

  Department of Biotechnology Engineering, International Islamic University Malaysia

• Alam Zahangir

  Department of Biotechnology Engineering, International Islamic University Malaysia

• Tawakalit Asiyanbi-Hammed

  Department of Biotechnology Engineering, International Islamic University Malaysia

関連論文

• Fatty Acid Profiles of Fin Fish in Langkawi Island, Malaysia
• Efficacy of Malaysian Plant Extracts in Preventing Peroxidation Reactions in Model and Food Oil Systems
• Determination of Lard in Mixture of Body Fats of Mutton and Cow by Fourier Transform Infrared Spectroscopy
• Storage Stability of Fish Oil from Langkawi Island, Malaysia
• Fucoxanthin Extractions of Brown Seaweeds and Analysis of Their Lipid Fraction in Methanol
• Effects of Season and Storage Period on Accumulation of Individual Carotenoids in Pumpkin Flesh (Cucurbita moschata)
• Cytotoxicity and Inhibition of Nitric Oxide in Lipopolysaccharide Induced Mammalian Cell Lines by Aqueous Extracts of Brown Seaweed

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