Posthyperventilation Hypoxemia after Methacholine Inhalation.
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概要
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The hypothesis of this study was that hypoxemia after methacholine (MTH) inhalation is related not only to ventilation/perfusion inhomogeneity, but also to posthyperventilation hypoxemia. To test the hypothesis, we paid special attention to changes in gas exchange and ventilation parameters after MTH inhalation. Six stable asthma patients were investigated, and Sa<SUB>O<SUB>2</SUB></SUB>, minute ventilation (VE), oxygen uptake rate in the lung (VO<SUB>2</SUB>), carbon dioxide output rate in the lung (VCO<SUB>2</SUB>), and respiratory exchange ratio (R) were measured. The Sa<SUB>O<SUB>2</SUB></SUB> level decreased from a baseline level (before MTH inhalation) of 96.8±1.0% (mean±SD) to the lowest level (the nadir Sa<SUB>O<SUB>2</SUB></SUB>) of 89.8±2.1% (p<0.01) in 200±50s after MTH inhalation and gradually increased toward the baseline level. VCO<SUB>2</SUB> increased just after MTH inhalation (post-MTH) with increased VE, and decreased at the nadir Sa<SUB>O<SUB>2</SUB></SUB> with baseline VE and Pa<SUB>CO<SUB>2</SUB></SUB>, indicating a decrease in breath-by-breath VA and an increase in dead space minute ventilation at the nadir Sa<SUB>O<SUB>2</SUB></SUB>, but VO<SUB>2</SUB> remained close to constant. R increased post-MTH, decreased at the nadir Sa<SUB>O<SUB>2</SUB></SUB>, and thereafter increased gradually toward the baseline level with a time constant of 5.6 min. The addition of CO<SUB>2</SUB> to inspired air partially suppressed hypoxemia. The consensus is that hypoxemia after MTH is solely attributable to the ventilation/perfusion inhomogeneity, but posthyperventilation hypoxemia is another reasonable interpretation of the hypoxemia after MTH with decreased VA, VCO<SUB>2</SUB>, and R. It is speculated that posthyperventilation normoventilation in respect to VCO<SUB>2</SUB> with baseline Pa<SUB>CO<SUB>2</SUB></SUB> after MTH inhalation resulted in posthyperventilation hypoxemia as a result of relative hypoventilation in respect to VO<SUB>2</SUB>.
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