Effects of pH on the Transport of 5-Fluorouracil across a Fibroin Membrane.
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The transport of 5-fluorouracil (an anti-cancer medicine, 5FU) through a protein membrane was investigated. The membrane was prepared from silk fibroin. The permeability coefficients of 5FU were measured at different <I>pH</I> values ranging from 3.0 to 9.0. The protein membrane was composed of both weak acid and weak base groups—a so-called amphoteric membrane. The isoelectric point of this membrane is about <I>pH</I> 4.0. The measured results showed that the permeability coefficient of 5FU abruptly decreased above about <I>pH</I> 7 because 5FU became anionic in an alkaline solution and the membrane become a cation exchanger above <I>pH</I> 4.0. The abrupt decrease in permeation can be theoretically explained in terms of the Donnan equilibrium and the Nernst-Planck equation. Fibroin membranes are suggested to be potentially very useful in drug delivery systems.
- 社団法人 繊維学会の論文
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