Optical Resolution of a d-Biotin Chiral Intermediate by Use of Lipoprotein Lipase.
スポンサーリンク
概要
- 論文の詳細を見る
An efficient optical resolution of (±)-(3aα,4α,6aα)-1,3-dibenzyl-3a,4,6,6a-tetrahydro-4-hydroxy-1<I>H</I>-thieno[3,4-<I>d</I>]imidazol-2(3<I>H</I>)-one [(<I>RS</I>)-<B>1</B>] was accomplished by acylation with lipoprotein lipase from <I>Pseudomonas aeruginosa</I> TE3285 in toluene. The lipase acylated (<I>R</I>)-<B>1</B> enantioselectively, and unreacted (<I>S</I>)-<B>1</B>, which is a chiral <I>d</I>-biotin intermediate, was isolated in excellent chemical and optical yields (>99% e.e.). Effects of acylating agents, water content and molecular sieves were also investigated.
- 公益社団法人 日本化学会の論文
公益社団法人 日本化学会 | 論文
- Spectrophotometric Studies on the Kinetics of Decomposition of Tetramethylmurexide in Acid Medium
- The Crystal Structures of Metal 8-Hydroxyquinolinate. I. Copper 8-Hydroxyquinolinate
- Hydrophile-Lipophile Balance Values for O/W Emulsions Stabilized by Nonionic Surfactants. I. Hydrophile-Lipophile Balance Values of Nonionic Surfactants Determined by Emulsification
- The Formation of Acetylenic Bond by the Elimination Reaction of Some Enol-esters. III. Formation of α, β-Acetylenic Carbonyl Compounds
- Ultraviolet Absorption Spectra of Lead Aldose-cysteinate