長期間プレドニン・エンドキサン療法を行っているWegener肉芽腫症の一例

概要

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A case of a 37-year-old farmer with Wegener's granulomatosis is reported. The nasal cavities, paranasal sinuses, gingivas, lungs and the skin were involved, but no evidence of renal disturbance was observed. He was initially treated orally with a daily dose of 30mg prednisolone in April, 1977. The patient also received electron irradiation with a total dose of 3000 rads because of persistent pain in the face. The irradiation partially remitted the disease, and the daily dose of prednisolone was decreased to 20mg. In September, 1977, another course of prednisolone, 50 mg daily, and cyclophoshpamide, 100mg daily, was administerd, since he developed general malaise, persistent fever, pain in the face and the pulmonary lesions. This treatment was so effective that tapering the dose of prednisolone and cyclophosphamide was attempted several times thereafter. Neither prednisolone nor cyclophosphamide could be entirely omitted. The patient eventually has been maintained on a daily dose of 30mg prednisolone and cyclophosphamide 50mg daily from March, 1981. He was able to return to farming and is free from the disease at present without singificant complications.
耳鼻と臨床会の論文