Possible intrinsic mechanisms underlying recovery from aphasia due to stroke

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The roles of the right non-dominant hemisphere and the residual areas of the damaged dominant left hemisphere have been discussed as to tthe recovery from aphasia. In this article, the results from our clinical investigations with positron emission tomography(PET)were reviewed in relation to the recovery from aphasia. In the long-term follow-up study with PET in patients with aphasia due to the left-hemisphere lesion who showed a gradual recovery, there was an increase in cerebral blood flow(CBF)and cerebral metabolic rate of oxygen(CMRO2)in the temporal and parietal cortices on the right hemisphere more than one year after the onset. The late increase in CBF and CMRO2in the right temporal and parietal cortices may indicate a possible compensatory role of the right hemisphere during the recovery from aphasia. In41patients with aphasia due to the left-hemisphere lesions, not only the mean CMRO2values from the left dominant hemisphere but also those from the right non-dominant hemisphere were significantly smaller in30patients with poor recovery than in11patients with a good recovery. Accordingly, a bilaterally reorganized language network may function effectively during the recovery from aphasia due to the left hemisphere lesion.
認知神経科学会の論文