Respiratory Infection of Laboratory Animals in Air Pollution Research
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概要
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Unfavorable occurrence of a variety of communicable diseases in experimentol animals hawe long been serious problem in every laberatory. It has been also true in the field of air pollution research, in which respiratory infection has been inevitably a major interest, under the situation that the most of all test materials should usually be administered through respiratory route.<BR>Possible difficulties arising from a contamination and/or provocation of respiratory infections, were presented and discussed. Special emphasis was made to mild or latent respiratory infections, which might easily lead to misunderstanding or even false-positive results in interpreting the obtained date from pathological, biochemical as well as respiratory-physiological examinations.<BR>Shift of longevity and incidence of pneumonia from several experimantal series in our laboratory during 1963 to 1973 were presented and interpreted from a view point of changing quality and way of sanitation of the animals. In using conventional animals and conventional control without any air-conditioning, fifty percents survival was only 7.8 months at around 1963 with 100% occurrence of pulmonary absess, which was main cause of spontaneous death of the animals. After a new animal house with complete airconditioning was established in 1966, fifty percents survivals were raised to 23.5-26.3 months and incidence of palmonary infections were lowered to 5-20 percents, the most of which were terminal events. Under more careful sanitary conditions including desinfections of food and water and other equipments, recent results from an inhalation experiment in using a SPF rat, showed 28 months in fifty percents survivals in control exposure group with practically clean lungs.<BR>It should be always born in mind that the quality of the experimental animals and microbiological environment of the animal facilities should be adequately matched in the sence of ecological situations. More <I>stable and practical</I> measure in microbiological control are urgently required for further fruitful development of experimental study in environmental research.
- 社団法人 大気環境学会の論文
社団法人 大気環境学会 | 論文
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