Leukoencephalopathy during Early Remission in a Case of Acute Lymphoblastic Leukemia with 1;19 Translocation.
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概要
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A 4-year-old boy was diagnosed in September, 1983 as having acute lymphoblastic leukemia (ALL) with 1 ; 19 translocation. Complete remission was obtained with VPL (vincristine, prednisolone, and L-asparaginase) therapy. Afterwards he received intrathecal administration of methotrexate and Ara-C (12 mg/m<SUP>2</SUP>, 20 mg/m<SUP>2</SUP> × 6), and whole-skull irradiation (2, 000 rad) for prophylaxis of CNS leukemia. Unconsiousness and convulsion developed 5 months after the onset of the treatment. Computed tomography and EEG demonstrated leukoencephalopathy. A survey of the literature, including our case, demonstrated a total of 3 ALL cases with 1; 19 translocation having a leukoencephalopathy during early remission. Some ALL cases with 1 ; 19 translocation may have a leukoencephalopathy following standard prophylactic therapy for CNS leukemia.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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