Studies on Urinary 8-hydroxydeoxyguanosine in Type 2 Diabetic Patients
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概要
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To clarify the clinical significance of urinary 8-hydroxydeoxyguanosine (8-OHdG), we measured urinary 8-OHdG by enzyme immunoassay in 73 patients with type 2 diabetes mellitus and 29 age-matched control subjects. We also studied the relationship between urinary 8-OHdG and different microproteins.<BR>The mean urinary 8-OHdG in the 73 diabetic patients was 12.8± 5.1μg/g. Ecr, significantly higher thanthat in the 29 control subjects (7.6±4.3, μg/g. Ecr, p<0.001). Urinary 8-OHdG correlated with hemoglobin Aic (r=0.356, p=0.0018). In contrast, urinary 8-OHdG did not correlate significantly with indicators of glomerular injury such as urinary transferrin and type IV collagen (r=-0.144 and r=-0.061) or with indicators of tubulointerstitial injury such as urinary N-acetyl-β-D-glucosaminidase activity andβ 2-microglobulin (r=-0.082 and r=-0.125).<BR>These results indicate that urinary 8-OHdG as an indicator of oxidative DNA damage may be affected by glycemic control rather than the severity of renal involvement withelevated urinary microproteins.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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