DNA Typing of HLA Using Sequencing-Based Typing (SBT)-HLA class II antigen gene is related to heterogeneity of Type 1 diabetes mellitus in Japanese children-:HLA class II antigen gene is related to heterogeneity of Type 1 diabetes mellitus in Japanese chi

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Sequencing-based typing (SBT) facilitates DNA typing of HLA. Using the Match Maker and MT Navigator in combination is particularly useful for rapid DQA 1, DQB 1, and DRB 1 typing, enabling larger numbers of specimens to be rapidly and accurately typed. To determine HLA-associated genetic factors in Japanese children with type 1 diabetes, we analyzed 166 patients with acute onset type 1 diabetes.Patients were divided into 3 groups by age at onset, i.e., 0-4, 5-9, and 10-15 years.Among them, significant positive association was seen in DQA 1*03-DQB 1*0303-DRB 1*0901, DQA 1*03-DQB 1*0401-DRB 1*0405 and DQA 1*03-DQB 1*0302-DRB I*0802 haplotypes and negative association in DQA 1*03-DQB 1*0302-DRB 1*0403, DQA 1*0102-DQB 1*0602-DRB 1*1501, DQA 1*0103-DQB 1*0601-DRB 1*1502 and DQA 1*0103-DQB 1*0601-DRB 1*0803 haplotypes. A significant positive association was seen in the DQA 1*03-DQB 1*0303-DRB 1*0901 haplotype and at onset at 0-4 years. Analysis by age of onset suggests that, in addition to the difference in clinical course and the positive rate for islet autoantibodies, a difference may exist in the roles of HLA class II antigen genes in onset and/or progression of β-cell destruction.
一般社団法人日本糖尿病学会の論文