A Case of Juvenile Onset Anti-GAD Antibody-Negative Diabetes Mellitus with 5 Recurrences of Diabetic Ketosis within 10 Years.
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概要
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A 20-year-old man was first admitted to our hospital due to diabetic ketoacidosis. Metabolic control improved with insulin injection, then insulin therapy was stopped. Diabetic ketosis recurred after 5 years and the man was hospitalized 4 times due to diabetic ketosis in the next 5 years. Antibodies against glutamic acid decarboxylase (GAD) and islet cells were negative in several examinations. Daily urinary C-peptide (CPR) was very low during admission but recovered to normal after insulin therapy. Body mass index (BMI) was almost normal and insulin resistance was not detected in the euglycemic insulin clamp test. Anamnesis before each admission revealed no excessive intake of sugar-containing soft drinks or diet failure. Oral glucose tolerance tests after improvement in diabetes control demonstrated decreased insulin secretion at an early phase. These findings suggest that transient but intense suppression of pancreatic insulin secretion probably caused the frequently recurrence of diabetic ketosis observed in this patient.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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