Serial Changes in Anti-islet Autoantibodies and Clinical Features of 3 Children with Asymptomatic Type 1 Diabetes.
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概要
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We studied changes of anti-islet autoantibody titers and clinical characterisics in 3 children with asymptomatic type 1 diabetes detected by urine glucose screening at school.<BR>At screening, they did not require insulin treatment because glucose intolerance was relatively mild. They initially showed positive results in anti-islet antibodies, ICA, and-GAD antibody, and anti-IA-2 antibody. During follow-up of 4 to 14 months after diagnosis, and insulin serum C-peptide gradually deteriorated and insulin was eventually administered to all. Accompanied by the decline in endogenous insulin secretion, titers of anti-islet autoantibodies fluctuated, apparently reflecting the destruction of β-cells, the alteration of islet-antigens, and the progression of diabetes.<BR>In a patient who started insulin treatment prior to reduced β-cell capacity early after diagnosis, the decline in antibody titers was slow, which may be associated with β-cell rest and antigen tolerance.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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