Are Possible Options for the Treatment of Diabetes Mellitus Improved by Glycemic Control?
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概要
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Many options for the treatment of diabetes mellitus (DM) became available in the 1990 s. Between 1993-1997, two types of α-glucose inhibitors (α-G I) and the thiazolidinedione (TZD) troglitazone were introduced in Japan. Biguanides (BG) gave been used in Japan for 39 years, however, they have recently been reevaluated following the introduction of the BG metformin in the USA in 1995. Moreover, a new pen-system type of insulin injection (novepen III<SUP>®</SUP>) became available in Japan in 1994.<BR>We compared the glycemic control of DM using HbA1c of 246 diabetic patients in 1991 with those of 394 patients in 1997. The mean HbA1c of all patients in 1997 (7.2±1.5%) was significantly lower than those in 1991 (7.9±1.7%)(p<0.001). In 1991, 97.1% of 136 patients treated with oral hypoglycemic agents (OHA) were treated with only sulfonylurea (SU), 2.2% only BG and 0.7% a combination of SU and BG. In 1997, 54.1% of 194 patients treated with OHA were given only SU, 3.6% BG, 2.1%α-G I, 2.1% TZD, and 38.1% a combination of these OHA. THe mean HbAic of OHA-treated patients in 1997 (7.4±1.3%) was significantly lower than that in 1991 (8.6±1.7%)(p<0.001). In 1991, only 6.1% of 82 patients were treated with insulin on combination with OHA, while in 1997, 34.6% of 107 patients were treated by combination therapy. The mean HbAic in 1997 (7.9 ± 1.6%) was significantly lower than that in 1991 (8.6±1.9%)(p<0.01). Thus, glycemic control is being sigmificantly improved using various options available for the treatment of DM.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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