Epidemiological Study on the Relationship Between Hyperinsulinemia and Cardiovascular Risk Factors-Tanno-Sobetsu Study.:Tanno Sobetsu Study
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To clarify the relationship between hyperinsulinemia and cardiovascular risk factors, medical examinations were performed on inhabitants (915 males and 1199 famales; aged 25-93 years; mean age, 59.3±11.1 years) of two agricultural communities in Hokkaido, Japan. Body height, body weight, blood pressure at sitting position (SBP, DBP), skin fold (SF), plasma glucose (FPG), plasma insulin (FIRI), serum total cholesterol (TC), serum triglyceride (TG), serum β-lipoprotein (β-LP) and serum HDL cholesterol (HDL) were assessed in the early morning. A 75g-oral glucose tolerance test (75g-OGTT) was also performed, and plasma glucose and plasma insulin were assessed at 60 -and 120-minute intervals (120PG, 120IRI).<BR>The prevalences of hypertension (HT), obesity (OB), hypercholesterolemia (HC) and hypertriglyceridemia (HTG) were significantly higher in the glucose intolerant group than in the normal glucose tolerant group. There were also significant positive correlations between 120IRI and SBP, DBP, TC, TG, β-LP, FPG, body mass index (BMI), and SF. The highest tritile of 120 IRI shows the highest in SBP, TC, TG, β-LP, SF and BMI, and prevalences of HT, HC and HTG in the highest tritile of 120 IRI are higher than in other tritiles. Multiple regression analyses indicated that 120IRI was a significant parameter of SBP, FPG, TC, HDL and BMI.<BR>From these results, we conclude that plasma hyperinsulinemia is closely related to cardiovascular risk factors through insulin resistance.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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