Relationship between Plasma Homocysteine Concentrations and Arteriosclerotic Risk Factors in Type II Diabetes Mellitus.
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Hyper-homocysteinemia has been recognized as one of the risk factors for atherosclerosis and premature vascular disease. Since hyper-homocysteinemia is directly related to the incidence of cardiovascular disease, we have investigated the possibility that its concentrations can modulate the development of atherosclerosis in patients with diabetes mellitus (DM). Seventy diabetic patients (36 males, 34 females, 61±9 years) without apparent renal insufficiency or hepatic involvement were studied. The control group was composed of 176 healthy normal subjects (95 males, 81 females, 51±9 years). Homocysteine levels were determined in plasma by the fluorometric highperformance liquid chromatography. The presence of aortic plaques was assessed by echocardiography by using a high resolution B-mode echo apparatus (HITACHI EUB-045, 10 Mhz linear array probe). Mean (±SD) levels of plasma homocysteine were no higher in DM group than in the control group. In diabetic patients, plasma homocysteine levels were positively correlated with serum creatinine and severity of diabetic retinopathy by multiple logistic regression analysis. Carotid intima-media thickness and plaque prevalent rate were significantly increased in diabetics than in normal subjects. Plasma homocysteine levels were significantly increased in plaque prevalent subjects.These results suggest that hyperhomocysteinemia may be induced in relation to aging and the degree of renal insufficiency, and may partially explain the observed accelaration of atherosclerosis in diabetic patients.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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