The Relationship between the Severity of Coronary Artery Lesions Evaluated by Coronary Angiography and Insulin Resistance Estimated by Glucose-Clamp Technique in Patients with Ischemic Heart Disease
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We determined insulin resistance using the euglycemic glucose-clamp technique in 40 patients with ischemic heart disease who underwent coronary angiography in our clinic between March 1996 and March 1997. We evaluated the severity of coronary artery lesions based on the number of damaged vessels, types of stenosis of the coronary artery, and presence of calcification in the coronary artery. The stenosis shape was divided into three types by using the classification of the American Heart Association (1993):(Type A, less than 10 mm, simple; type B, 10-20mm, moderate; type C, longer than 20 mm, severe, diffuse, complicated). The average glucose infusion rate (mean glucose infusion rate, M-value) in patients with two-or three-vessel disease was significantly less than that in patients with one-vessel disease, and the M-value was lower in patients with type B or C lesions than in those with type A lesions. In addition, the M-value in patients with calcification of the coronary artery was lower than that in patients without calcification, but this difference was not significant. These findings suggest that insulin resistance is related to the development of ischemic heart disease.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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