Effect of Oral Hypoglycemic Agents on Fat Distribution and Glucose Tolerance in Non-Insulin-Dependent Diabetes Mellitus Patients.
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To evaluate the efficacy of acarbose (A) and glibenclamide (G) in NIDDM, we examined the effect of A and G on visceral fat accumulation and insulin resistance in NIDDM patients. We divided 41 NIDDM patients who had not received any diabetic medication into two groups. The 14 mild cases were treated with A (150-300mg/day), and the others were treated with G (1.25-7.5mg/day) and followed for 24 weeks. We evaluated visceral fat area (VF), subcutaneous fat area (SF), and the VF/SF ratio by abdominal CT at the level of the umbilicus. Insulin resistance was evaluated by the oral glucose tolerance test. Body mass index (BMI) after treatment in the A group had decreased significantly (p<0.05) compared to before treatment, but did not change significantly in the G group. The VA (139.4±67.0cm<SUP>2</SUP>) and the VA/SA ratio (1.000±0.428) after treatment in the G group were significantly (p<0.05) increased compared with the VA (102.4±52.3cm<SUP>2</SUP>) and the VA/SA ratio (0.770±0.444) before treatment. They were also decreased in the A group, but not significantly. An oral glucose tolerance test after treatment showed a significant decrease in plasma glucose levels (PG) in both groups and a significant increase in plasma insulin level (PI) after glucose load in the G group, but a decrease in PI in the A group compared with before treatment. In conclusion, gliben-clamide treatment resulted in significant worsening of visceral fat accumulation and hyperinsulinemia in NIDDM patients, whereas acarbose treatment resulted in significant improvement.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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