Long-term Prognosis for Diabetics in the General Population of Two Rural Communities in Japan. A Prospective Eighteen-year Follow-up Study.:A Prospective Eighteen-year Follow-up Study
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概要
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Long-term prognoses were compared in individuals with and without glucose intolerance in the general population of two rural Japanese communities, Tanno and Sobetsu. A prospective cohort study of 1, 996 men and women between the ages of 40 and 64 years at the baseline examination was conducted over an 18-year period, from 1977 to 1995. During this follow-up study, 177 people dropped out, leaving 1, 819 cases available for statistical analysis. In the first year of the study, 885 cases were diagnosed as normal glucose tolerant (NGT), 798 cases as borderline diabetic (BDM), and 113 cases as diabetic (DM). Of the 1, 819 subjects, 256 died during the 18-year period. The main cause of death in glucose intolerant (BDM&DM) subjects was malignant neoplasms, followed by cardiovascular disease, and cerebrovascular disease. The survival curve for subjects with glucose intolerance was lower than for those without glucose intolerance. Cox's hazard regression model revealed a significant association between glucose intolerance and fatal events (relative risk 1.43: 95% CI 1.02-2.00) only in men. The survival curve for the end point of cardiovascular mortality in subjects with glucose intolerance was lower thant that in those without glucose intolerance (p<0.05).
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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