Impairment of Left Ventricular Regional Wall Motion in Diabetes Mellitus without Coronary Artery Disease.
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概要
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To elucidate the mechanisms of diabetic cardiomyopathy, dual SPECT imaging with thallium-201 (T1-201) and I-123 beta-methyl-p-iodophenyl pentadecanoic acid (BMIPP), a branched analogue of free fatty acid (FFA), and dipyridamole-infusion T1-201 scintigraphy were performed in 28 NIDDM patients without coronary artery disease. Twenty eight patients were divided-into two groups based on the presence of wall motion abnormalities on cineangiographic leftventriculography (LVG). Nineteen patients with normal wall motion documented on LVG (group A) out of 28 evaluated patients demonstrated normal T1-201 and I-123 BMIPP uptake in dual SPECTimaging, whereas 9 patients with reduced wall motion (group B) demonstrated reduced I-123 BMIPP uptake when compared with T1-201 uptake. On dipyridamole-infusion T1-201 scintigraphy, transient perfusion defects were demonstrated in 4 patients of group B and two patients of group A (p< 0.05). These results suggest that small vessel disease and the impairment of myocardial free fatty acid metabolism are etiologic or contributory factors for regional wall motion abnormality in diabetic cardiomyopathy.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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