A Case of Diabetes Mellitus and Sensory Hearing Loss with the 3243 (A.RAR.G) Mutation in Mitochondrial DNA and Subsequent Manifestation of Mitochondrial Encephalomyopathy (MELAS).:DNA and Subsequent Manifestation of Mitochondrial Encephalomyopathy (MELAS)
スポンサーリンク
概要
- 論文の詳細を見る
We report a case of diabetes mellitus and sensory hearing loss exhibiting the 3243 (A→G) mutation in mitochondrial DNA with subsequent manifestation mitochondrial encephalomyopathy (MELAS). The patient experienced sensory hearing loss and was diagnosed with diabetes mellitus that required insulin therapy in his twenties. At age 33, he was admitted because of loss of consciousness. Elevated concentrations of lactic acid and pyruvic acid were found in his cerebrospinal fluid and ragged-red fibers were observed in a biopsied muscle specimen. We identified a 3243 (A→G) mutation in mitochondrial DNA isolated from peripheral leucocytes and the muscle specimen, and a diagnosis of MELAS was made.<BR>The 3243 (A→G) mutation in mitochondrial DNA causes diabetes mellitus and sensory hearing loss, as well as MELAS. It is generally accepted that MELAS is a rare complication in the subgroup of diabetes mellitus patients with sensory hearing loss. However our findings show the diversity of the clinical manifestations of the 3243 (A→G) mutation and the necessity of careful follow-up of patients in the subgroup with diabetes and sensory hearing loss.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
- Hyperlipidemia and Analysis of the Use of Lipid-lowering Drugs in Non-insulin-dependent Diabetes Mellitus.
- Thyrotoxic Crisis in a Patient with Mitochondrial Diabetes Mellitus.
- Rapidly Progressive Nephropathy in a Young Patient with Mitochondrial Gene Mutation.
- An Autopsy Case of Ketoacidosis in Insulin Dependent Diabetes Mellitus Patient Complicated with Adult Respiratory Distress Syndrome, DIC and Leukopenia.
- Studies on Alcoholic Beverages in Relation to Body Weight for Mild Diabetics