A Case of IDDM due to Congenital Hypoplasia of the Dorsal Pancreas with Congenital Common Bile Duct Dilatation.
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We report a case of dorsal pancreatic hypoplasia complicated by common bile duct dilatation and insulin-dependent diabetes mellitus in a 25-year-old woman. The patient was admitted to our hospital because of thirst and fatigue. She was alert at admission, but laboratory findings revealed a fasting blood glucose level of 332mg/d<I>l</I>, ketosis and liver dysfunction (GOT 61u/<I>l</I>, GPT 68u/<I>l</I>, ALP 654u/<I>l</I>, LAP 582u/<I>l</I>). Abdominal ultrasonography revealed common bile duct dilatation and endoscopic retrograde cholangiopancreatography showed congenital hypoplasia of the dorsal pancreas with common bile duct dilatation. As endogenous insulin secretion was severely decreased based on the results of urinary c-peptide secretion and glucagon loading test, intensive insulin therapy was prescribed for glycemic control. Congenital hypoplasia of the dorsal pancreas associated with diabetes mellitus has been reported in 19 cases throughout the world. According to our knowledge, this report is the first of type I diabetes with congenital hypoplasia of the dorsal pancreas and common bile duct dilatation describing histopathological evidence of islet hypoplasia without insulitis.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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