Pathogenesis of Glucose Intolerance Associated with Klinefelter Syndrome. Euglycemic Hyperinsulinemic Clamp Study in Two Klinefelter Syndrome Cases.:Euglycemic Hyperinsulinemic Clamp Study in Two Klinefelter Syndrome Cases
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Klinefelter syndrome (KS) is often associated with diabetes mellitus. The pathogenesis of glucose intolerance associated with KS is not well known. We examined insulin secretion by estimatillg 24-hour urinary C-peptide and 75g-oral glucose tolerance test (OGTT), and insulin sensitivity by euglycemic hyperinsulinemic clamp study, in two non-obese patients with KS. The first case, a 54-year-old, was diagnosed as diabetic according to the criteria of the Japan Diabetes Society. The second case, a 45-year-old, was diagnosed as a borderline diabetic. Both had been diagnosed as KS by sex chromosome analysis. The former case was treated with a sulfonylurea drug, the latter with diet only. Values of 24-hour urinary C-peptide were 96.4μg/day and 42.2μg/day, respectively, and peak serum values of immunoreactive insulin during the OGTT were not significantly depressed (50μU/m<I>l</I> and 79μU/m<I>l</I>, respectively). Metabolic clearance of glucose was impaired in these patients (7.0m<I>l</I>/kg/min and 6.3m<I>l</I>/kg/min, respectively; normal value, 11.7±4.9m<I>l</I>/kg/min, mean±SD).<BR>These results suggest that the main cause of the glucose intolorence associated with KS is insulin resistance rather than decreased insulin secretion.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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