Mechanism of Nerve cAMP Content Reduction in Streptozocin Induced Diabetic Rats.
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It has been reported that nerve cAMP content is reduced in streptozocin-induced diabetic rats and that cAMP might regulate the activity of nerve Na/K-ATPase. To clarify the mechanism by which nerve cAMP content is reduced in diabetes, immunohistochemical and biochemical experiments were conducted. Using polyclonal anti-cAMP antibody, cAMP was shown to be visualized exclusively in axons. The cAMP content was significantly reduced in the distal stumps of transected nerves in which axons were lost due to Wallerian degeneration, but did not differ between control and diabetic nerves. Although adenylate cyclase and cAMP-phosphodiesterase activities were not altered in diabetic nerves, the accumulation of cAMP under isoproterenol stimulation was significantly decreased in diabetic nerves. These results suggest that in diabetes axonal cAMP might be decreased and that altered signal transduction from receptors to adenylate cyclase might be responsible for the reduced nerve cAMP content.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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