Histological Study of Retinal Vascular Changes in Diabetic Rats Fed a High Cholesterol Diet.
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Histological changes in the retinal tissue and serum levels of lipid and glucose were investigated. STZ-induced diabetic rats were given regular chow plus water for 4weeks and subsequently grouped according to the following diet regimens.<BR>Group 1: non-diabetic rats, Group 2: diabetic rats fed no additional cholesterol or glucomannan, Group3: diabetic rats fed or additiona l1.5% cholesterol, Group 4: diabetic rats fed both the addititonal 1.5% cholesterol and 15% glucomannan. Group1 received only regular chow and served as a control.<BR>In the 18th week, all rats were sacrificed and chemical analyses of blood samples were conducted. Selected portions of the retina including the chorioidea were histologicaly examined. Plasma glucose and total cholesterol levels of Group 3 were significantly higher than those of Group 4. In accordance with the results of the chemical analysis, microvascular changes such as dilatation or occlusion of the Arteriola-and Venula medialis retinae were found in diabetic rats of Groups 3 and 4. However, diabetic vascular changes of Group 2 were evident only in the Venula medialis retinae. Furthermore, atheromatous plaque in the Aa. choriodea retinae (A. ciliares posterior longae) was observed in Groups 3 and 4. As shown in Groups 3 and 4, atherosclerosis of the A. ciliares posterior longae was found in cases with high cholesterolemia. This may reflect macroangiopathy and is probably related to the progression of microangiopathy.<BR>A high-fiber diet using glucomannan as a supplement may be effective in lowering lipid and glucose levels and preventing microvascular changes.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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