Hypoglycemic Attacks after Administration of Bezafibrate in Three Cases of Non-Insulin Dependent Diabetes Mellitus.
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We report three cases of non-insulin-dependent diabetes mellitus who experienced frequent attacks of hypoglycemia after administration of bezafibrate for hyperlipideniia.Although they had been treated with glibenclamide, glycemic control was unsatisfactory in all three, and one patient was considered a sulfonylurea failure.Several days after the addition of bezafibrate, blood glucose levels decreased, even to the point of hypoglycemia.Therefore, 2.5mg of glibenclamide was changed to500mg of tolbutamide in case 1, 6.25mg of glibenclamide was reduced to 2.5mg in case 2, and 10mg of glibenclamide and 100mg of buformin were stopped in case 3.These patients subsequently maintained good glycemic control without hypoglycemia.<BR>As all of these cases were elderly and two of them had mild renal dysfunction, clearances of glibenclamide and bezafibrate were assumed to be decreased.Therefore, it was suggested that the hypoglycemic effects of glibenclamide and bezafibrate were potentiated due to elevated plasma levels of these drugs and exaggerated drug-interactions.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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