A Case of Slowly Progressive IDDM in the Progress of Serial Autoimmune Diseases.
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概要
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A 54-year-old woman was diagnosed with idiopathic thrombocytopenic purpura (ITP) in 1968, rheumatoid arthritis (RA) in 1971, and non insulin-dependent diabetes mellitus (NIDDM) in 1985. She was admitted with hyperglycemia and ketosis, because blood sugar control of NIDDM with urine c-peptide of 36ug per day had gradually become unstable since 1989. On admission, chemical studies of her diabetes mellitus showed less than 10ug per day of urine c-peptide and no response to the glucagon test. She had also experienced 6 abortions and premature births. Laboratory data showed positive findings of islet cell antibody, antiplatelet antibody, rheumatoid factor, and lupus anticoagulant. A diagnosis of antiphospholipid (aPL) syndrome was made on the basis of laboratory data and past history. Non Insulin-dependent dabetes melltus with aPL syndrome, ITP and RA resulted slowly progressive IDDM. The dose of glucocorticoid was increased, and she received intensive conventional insulin therapy. This case is very interesting in regard to the mechanisms of onset of serial autoimmune diseases.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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