Detection of Late Potential in NIDDM Patients Using Signal Averaged Electrocardiography.
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Late potentials were measured by signal-averaged electrocardiography (SAE) in 110 patients with non-insulin-dependent diabetes mellitus (NIDDM) with or without microvascular complications and 50 healthy, age matched control subjects. The results of SAE were considered positive if either the duration of filtered QRS (f-QRS) waves was longer than 130 msec or the root mean square (RMS) of the amplitude in the last 40 msec was less than 15μV.<BR>In NIDDM patients, the LP-positive rate was significantly higher than that in the control group [27% vs.4%, p<0.01]. LP-positive NIDDM patients had a significantly longer duration of disease and a significantly higher rate of retinopathy than LP-negative diabetics (p<0.05). The SAE results showed no significant correlations with blood pressure, serum lipid level or the HbA<SUB>1</SUB>c level. For evaluation of myocardial circulation, single photon emission computed tomography (SPECT) with <SUP>201</SUP>T1 was carried out. In the LP-positive NIDDM patients, the washout rate of <SUP>201</SUP>T1 clearance tended to be slower, and diffuse defects unrelated to the major coronary vessels were noted at a high rate (53.6%, 15/28).<BR>This is the first reported study demonstrating that NIDDM patients with diabetes mellitus of long duration and/or microvascular lesions have a significantly higher rate or positive SAE findings. Although further study is necessary, SAE may be a useful and non-invasive method of detecting diabetic cardiac lesions.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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