Studies on a Diabetic Strain of Rat (WBN/Kob). 16th Report: Relationship between Dietary Fiber Intake and Development of Diabetes.:Relationship between Dietary Fiber Intake and Development of Diabetes
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We compared the effects of two kinds of commercial diets, termed MM3 for "long-term rearing"(high fiber diet) and MB3 for "special breeding"(low fiber diet), on the development of spontaneously occurring diabetes in WBN/Kob rats. Male WBN/Kob rats were fed MM3 or MB3 after weaning. Although there was no significant difference in peak body weight between the two groups, body weight in the MB3-fed group reached a peak earlier than that in the MM3-fed group. Food intake in both groups increased after the onset of diabetes. Before the onset of diabetes, although there was no significant difference in caloric intake between the two groups, a remarkable difference in dietary fiber intake was observed. At 14 weeks of age, the MB3-fed group showed glucose intolerance while the MM3-fed group did not. At 40 and 54 weeks of age, glucose tolerance in the MB3-fed group was more impaired than that in the MM3 fed group. Morever, the IRI response during OGTT in the MB3-fed group was lower than that in the MM3-fed group.<BR>These data suggest that the difference in diabetes development between rats on the two kinds of diet might be caused by differences in dietary fiber intake.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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