Preventive Effect of Food Restriction on Development of Nephropathy in Streptozotocin-induced Diabetic Rats.:induced Diabetic Rats
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To clarify whether glycemic control prevents the development of nephropathy in streptozotocin-induced diabetic rats (STZ rats), changes in the urinary albumin excretion rate (UAE) were observed for 4 weeks, and the number of anionic sites (AS) on lamina rara externa of the glomerular basement membrane (GBM) was evaluated at the end of the experiment in the following three groups: normal controls, food non-restricted STZ and food restricted STZ rats.UAE of the food non-restricted STZ rats was markedly increased at the end of the experiment, whereas elevation of UAE was suppressed (p<0.03) in the food restricted STZ rats.The number of AS on GBM was significantly (p<0.001) decreased in the food non-restricted STZ rats, as compared to that of normal control rats.However, the decrease in number of AS in the food restricted STZ rats was less than that of the food non-restricted STZ rats (p<0.05).<BR>From these results, it can be concluded that control of plasma glucose by food restriction may act so as to prevent decreases in heparan sulfate proteoglycan of the GBM and, hence, to suppress increased permeability of the GBM.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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