Effect of Granulocyte-colony Stimulating Factor(G-CSF) on the Generation of Oxygen-derived Free Radicals in Neutrophils from Streptozotocin-induced Diabetic Rats.
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To evaluate whether granulocyte-colony stimulating factor (G-CSF) improves impaired production of oxygen-derived free radicals by diabetic neutrophils, we studied the effect of G-CSF on chemiluminescence amplified by a luciferin analog (CLA-DCL) and luminol (L-DCL) in response to fMLP in neutrophils from streptozotocin (STZ)-induced diabetic (DM) rats.Both CLA-DCL and L-DCL were significantly reduced in DM neutrophils and L-DCL was more sensitive to this inhibition than CLA-DCL.In both control and DM neutrophils, G-CSF did not change the basal chemiluminescence, however, it apparently primed CLA-DCL and L-DCL.Although in diabetic neutrophils the priming effect of G-CSF on both CLA-DCL and L-DCL was less compared with that in control neutrophils, L-DCL was more sensitive to this priming effect than CLA-DCL.Because bacterial infection still accounts for the susceptibility to infection and is an important cause of morbidity and mortality in diabetic patients, these data suggest that G-CSF may be a useful drug to prevent aggravation of bacterial infection in diabetic patients.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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