Urinary Transferrin and Albumin Excretion Rates in Type-2 Diabetics.
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We measured the concentration of transferrin (TF), albumin (Alb), A microglobulin (AM), and creatinine (Cr) in first-voided morning urine samples from 61type-2diabetic patients and19normal subjects. We also determined urinary Alb and TF excretion rates before and after treatment in 6 diabetic patients.<BR>In the 34 adequate glycemic control patients (HbA<SUB>1</SUB>c<8.0%), a significant correlation was found between the urinary TF/Cr and β<SUB>2</SUB>M/Cr ratios (r=0.46, p<0.02), but no significant correlation was detected between the urinary Alb/Cr and AM/Cr ratios. The urinary TF/Alb ratio was higher in the 17 adequate glycemic control patients with microalbuminuria than in the17adequate control patients with normoalbuminuria (p<0.01). An elevated urinary TF/Alb ratio was correlated with an elevated urinary Alb/Cr ratio (r=0.61, p<0.02). Among the 28 patients with normoalbuminuria, the urinary TF/Cr and TF/Alb ratios were higher in the 17 adequate glycemic control patients than in the II poor glycemic control patients. In 6 patients, the posttreatment urinary TF/Cr and TF/Alb ratios were significantly lower than the pretreatment ratios (p<0.02).
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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