Effect of Long-term Treatment with Continuous Subcutaneous Insulin Infusion(CSII) on Progression of Diabetic Complications in IDDM.
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This study was disigned to reevaluate the effect of long-term CSII treatment on the progression of diabetic complications. Seven IDDM patients treated with multiple insulin injection therapy before CSII began, have been followed-up for 76.3±20.1 (M±SD) months.<BR>The HbA<SUB>1</SUB>c value, averaged per year for each patient (10.1±2.7%at entry), fell significantly to 7.1±1.7%(p<0.01) during the first year and showed a sustained significant decrease over the succeeding seven years of CSII treatment. The progression of diabetic complications was reevaluated. Retinopathy: improved in 2, unchanged in 3 (including 2 subjects with transient deterioration during the 6 months after CSII initiation) and slight progression in 2. Nephropathy: 2 of 3 patients with microalbuminuria (MA) improved to normoalbuminuria (NA) and in one low range persisted MA. Three of 4 patients with NA remained stable and one progressed to low range MA. Neuropathy: mean value of motor nerve conduction velocity improved significantly;from 46.9±2.6 m/s at entry to 54.4±0.8 m/s at the end of the follow-up period.<BR>We conclude that long-term CSII therapy is well accepted by IDDM patients and can result in significant improvement of metabolic control. Furthermore, it may delay or prevent the early stage of diabetic complications.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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