The measurement of erythrocyte membrane charge by alcian blue in diabetic patients, and it's significance.
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To investigate whether the negative surface charge of the erythrocyte membrane is reduced in parallel with the progression of diabetic nephropathy, we measured the negative surface charge of the erythrocyte membrane in diabetic patients with different urinary albumin excretion rates (AER) by the modified alcian blue method. According to a recent recommendation at a consensus conference, the diabetic patients were divided into three groups: those with normoalbuminuria (less than 20μg/min), those with microalbuminuria (20-200μg/min) and those with macroalbuminuria (more than 200 pg/min). The negative surface charges in each group were 0.235±0.023, 0.229±0.028 and 0.234±0.026, respectively. There were no correlations between the negative surface charge of the erythrocyte membrane and AER or between the negative surface charge of the erythrocyte membrane and the severity of retinopathy. But there was a negative correlation between the negative surface charge and the level of HbAic that was measured one month later. These results suggest that the negative surface charge of the erythrocyte membrane dose not reflect the severity of microangiopathy.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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