Impaired Phagocytic Activity of Circulating Polymorphonuclear Neutrophils in Patients with Diabetes Mellitus.
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The phagocytic activity of the polymorphonuclear neutrophils (PMN) was studied by the rapid method using <I>Micrococcus lysodeikticus (M. lys) </I> of 106 diabetics (insulin: 34, oral hypoglycemic agents: 51, diet: 21) and 60 controls. Heparinized blood was incubated with <I>M. lys</I> in saline containing 6% hydroxyethyl starch for up to 10 minutes. During incubation, samples were taken at 1 min intervals for quantitative evaluation of phagocytosis. A phagocytosis level of 100% was found within 7 min after the start of incubation in all of the controls, and phagocytosis levels less than 100% at 7 min were assessed as impaired.<BR>Impaired phagocytosis was found in 44.3%(47/106) of the diabetics.The duration of diabetes in patients with impaired phagocytosis was significantly longer than in those with normal phagocytosis (14.8±1.1 year vs 11.8±1.0 years, p<0.05). There wasno difference between the FPG and glycosylated hemoglobin levels of patients with impaired phagocytosis and patients with normal phagocytosis. The plasma β-hydroxybutyrate concentration of patients with impaired phagocytosis was significantly higher than in those with normal phagocytosis (81.0±14.8μmol/<I>l</I> vs 46.4±7.3μmol/<I>l</I>, p<0.05). When washed PMNs obtained from patients with impaired phagocytosis were suspended in plasma from controls, the impaired phagocytosis improved markedly.<BR>These findings suggest that the impairment of phagocytosis in diabetics may be due to humoral factors and not to the PMNs themselves.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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